Bone marrow transplantation for constitutional pure red cell aplasia

Bone marrow transplantation for constitutional pure red cell aplasia.

Constitutional pure red cell aplasia (CPRCA) is a syndrome of failed erythropoiesis usually diagnosed within the first year of life. Four patients with CPRCA received transplants with marrow from their HLA-identical, mixed lymphocyte culture-nonreactive siblings. All patients were resistant to corticosteroid therapy and were dependent on regular red cell transfusions for at least 5 years. Three...

High-dose intravenous methylprednisolone for constitutional pure red cell aplasia.

I read with interest the recent article by Lenarsky et al’ about bone marrow transplantation (BMT) for Diamond-Blackfan syndrome. I reported a case of constitutional pure red cell aplasia (CPRCA) refractory to conventional prednisone (2 mg/kg) administration treated with high-dose intravenous (IV) methylprednisolone (HIVMP) (30 mg/kg for 3 days, 20 mg/kg for 4 days, then subsequently 10, 5, and...

Pure red cell aplasia of long duration complicating major ABO-incompatible bone marrow transplantation.

In 3 of 15 consecutive patients receiving a human leukocyte antigen (HLA)-identical but major ABO incompatible bone marrow transplant (BMT), pure red cell aplasia (PRA) lasting 5 to 8 months was observed. Titers of the incompatible anti-A agglutinin before infusion of the red blood cell (RBC)-depleted BMT was very high in one, and in the usual range in two patients. Decrease of agglutinin titer...

Acquired pure red cell aplasia.

Correspondence MEDICALTJOSRNAL 559 Acquired Pure Red Cell Aplasia SIR,-May we make the following observation about your article on acquired pure red cell aplasia and its treatment with steroids (6 April, p. 3) ? A pure red cell aplasia that responded to riboflavine or prednisone has been described in African adults and in children with marasmus and kwashiorkor.' In marasmus and kwashiorkor an e...

Cyclosporine for pure red cell aplasia.